Publications

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ORCID: 0000-0003-2731-4707

Bauer CC, Minard A, Pickles IB, Simmons KJ, Chuntharpursat-Bon E, Burnham MP, Kapur N, Beech DJ, Muench SP, Wright MH, Warriner SP, Bon RS  Xanthine-based photoaffinity probes allow assessment of ligand engagement by TRPC5 channels RSC Chem Biol 2020, 1, 436-448
DOI:10.1039/D0CB00126K

Bell AS, Y. Zhiyong, Hutton JA, Wright MH, Brannigan JA, Paape D, Roberts SM, Sutherell CL, Ritzefeld M, Wilkinson AJ, Smith DF, Leatherbarrow RJ, Tate EW  Novel Thienopyrimidine Inhibitors of Leishmania N-Myristoyltransferase with On-Target Activity in Intracellular Amastigotes J Med Chem 2020, 63, 7740-7765
DOI:10.1021/acs.jmedchem.0c00570

Foyer CH, Baker A, Wright MH, Sparkes IA, Mhamdi A, Schippers JHM, Van Breusegem F On the move: redox-dependent protein relocation in plants J Exp Bot 2020, 71, 620-631
DOI:10.1093/jxb/erz330

Wright MH Chemical proteomics of host‐microbe interactions Proteomics 201818, 1700333
DOI:10.1002/pmic.201700333

Foyer CH, Wilson MW, Wright MH Redox regulation of cell proliferation: Bioinformatics and redox proteomics approaches to identify redox-sensitive cell cycle regulators Free Rad Biol Med 2018, 122, 137-149
DOI:10.1016/j.freeradbiomed.2018.03.047

Wright MH, Tao Y, Drechsel J, Krysiak J, Chamni S, Weigert-Munoz A, Harvey NL, Romo D, Sieber SA Quantitative chemoproteomic profiling reveals multiple target interactions of spongiolactone derivatives in leukemia cells Chem Commun 201753, 12818-12821
DOI:10.1039/C7CC04990K

Wright MH, Fetzer CF, Sieber SA Chemical Probes Unravel an Antimicrobial Defense Response Triggered by Binding of the Human Opioid Dynorphin to a Bacterial Sensor Kinase J Am Chem Soc 2017139, 6152-6159
DOI:10.1021/jacs.7b01072

Wright MH, Paape D, Price HP, Smith DF, Tate EW Global profiling and inhibition of protein lipidation in vector and host stages of the sleeping sickness parasite trypanosoma brucei ACS Infectious Diseases 20162, 427-441
DOI:10.1021/acsinfecdis.6b00034

Lehmann J, Wright MH, Sieber SA Making a Long Journey Short: Alkyne Functionalization of Natural Product Scaffolds Chemistry – A European Journal 2016, 22, 4666-4678
DOI:10.1002/chem.201504419

Wright MH, Sieber SA Chemical proteomics approaches for identifying the cellular targets of natural products Natural Product Reports 2016, 33,  681-708
DOI:10.1039/c6np00001k

Wright MH, Paape D, Storck EM, Serwa RA, Smith DF, Tate EW Global analysis of protein N-myristoylation and exploration of N-myristoyltransferase as a drug target in the neglected human pathogen Leishmania donovani Chemistry and Biology 2015, 22, 342-354
DOI:10.1016/j.chembiol.2015.01.003

Hutton JA, Goncalves V, Brannigan JA, Paape D, Wright MH, Waugh TM, Roberts SM, Bell AS, Wilkinson AJ, Smith DF, Leatherbarrow RJ, Tate EW Structure-based design of potent and selective Leishmania N-myristoyltransferase inhibitors Journal of Medicinal Chemistry 201457, 8664-8670
DOI:10.1021/jm5011397

Thinon E, Serwa RA, Broncel M, Brannigan JA, Brassat U, Wright MH, Heal WP, Wilkinson AJ, Mann DJ, Tate EW Global profiling of co- and post-translationally N-myristoylated proteomes in human cells Nature Communications 2014, 5, 4919
DOI:10.1038/ncomms5919

Guttery DS, Poulin B, Ramaprasad A, Wall RJ, Ferguson DJP, Brady D, Patzewitz EM, Whipple S, Straschil U, Wright MH, Mohamed AMAH, Radhakrishnan A, Arold ST, Tate EW, Holder AA, Wickstead B, Pain A, Tewari R Genome-wide functional analysis of Plasmodium protein phosphatases reveals key regulators of parasite development and differentiation Cell Host and Microbe 201416, 128-140
DOI:10.1016/j.chom.2014.05.020

Wright MH, Clough B, Rackham MD, Rangachari K, Brannigan JA, Grainger M, Moss DK, Bottrill AR, Heal WP, Broncel M, Serwa RA, Brady D, Mann DJ, Leatherbarrow RJ, Tewari R, Wilkinson AJ, Holder AA, Tate EW Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach Nature Chemistry 2014, 6, 112-121
DOI:10.1038/nchem.1830

Tate EW, Bell AS, Rackham MD, Wright MH N-Myristoyltransferase as a potential drug target in malaria and leishmaniasis Parasitology 2014141, 37-49
DOI:10.1017/S0031182013000450

Poulin B, Patzewitz EM, Brady D, Silvie O, Wright MH, Ferguson DJP, Wall RJ, Whipple S, Guttery DS, Tate EW, Wickstead B, Holder AA, Tewari R Unique apicomplexan IMC sub-compartment proteins are early markers for apical polarity in the malaria parasite Biology Open 2013, 2, 1160-1170
DOI:10.1242/bio.20136163

Morkunas B, Galloway WRJD, Wright M, Ibbeson BM, Hodgkinson JT, O’Connell KMG, Bartolucci N, Valle MD, Welch M, Spring DR Inhibition of the production of the Pseudomonas aeruginosa virulence factor pyocyanin in wild-type cells by quorum sensing autoinducer-mimics Organic and Biomolecular Chemistry 201210, 8452-8464
DOI:10.1039/c2ob26501j

Hodgkinson JT, Galloway WRJD, Wright M, Mati IK, Nicholson RL, Welch M, Spring DR Design, synthesis and biological evaluation of non-natural modulators of quorum sensing in Pseudomonas aeruginosa Organic and Biomolecular Chemistry 201210, 6032-6044
DOI:10.1039/c2ob25198a

Price HP, Hodgkinson MR, Wright MH, Tate EW, Smith BA, Carrington M, Stark M, Smith DF A role for the vesicle-associated tubulin binding protein ARL6 (BBS3) in flagellum extension in Trypanosoma brucei Biochimica et Biophysica Acta – Molecular Cell Research 20121823, 1178-1191
DOI:10.1016/j.bbamcr.2012.05.007

Heal WP, Wright MH, Thinon E, Tate EW Multifunctional protein labeling via enzymatic N-terminal tagging and elaboration by click chemistry Nature Protocols 2012, 7, 105-117
DOI:10.1038/nprot.2011.425

Heal WP, Jovanovic B, Bessin S, Wright MH, Magee AI, Tate EW Bioorthogonal chemical tagging of protein cholesterylation in living cells Chemical Communications 201147, 4081-4083
DOI:10.1039/c0cc04710d

Wright MH, Heal WP, Mann DJ, Tate EW Protein myristoylation in health and disease Journal of Chemical Biology 20103, 19-35
DOI:10.1007/s12154-009-0032-8

Evans AC, Skey J, Wright M, Qu W, Ondeck C, Longbottom DA, O’Reilly RK Functional and tuneable amino acid polymers prepared by RAFT polymerization Journal of Polymer Science, Part A: Polymer Chemistry 200947, 6814-6826
DOI:10.1002/pola.23721